New research project AdInKranio launched

The AdInKranio research project aims to develop innovative, customized implants for the treatment of large skull defects. Conventional methods for reconstructing these defects regularly reach their limits, failing to meet the individual patient needs in terms of shape, size, and biocompatibility.

This project aims to develop new, adaptive implants that can be adapted to the specific requirements of each patient. The focus is on establishing a consistent and efficient process chain that enables the rapid and precise production of such implants. This will utilize a particularly innovative technology variant of additive manufacturing (3D printing), which also offers a high degree of flexibility.

A unique feature of the implants to be developed is their multi-part design, which allows them to be flexibly adapted to different conditions. This modularity is crucial, especially in the treatment of children, whose skull shape and size are subject to change as they grow. The implants should be able to adapt to changing conditions without the need for additional surgical interventions. In addition, the implants are designed to combine several advantageous material properties – a dense layer to protect the brain and a porous layer that promotes bone growth, thus improving the integration of the implant into the skull bone.

To find the best possible solution, the project is researching methods for dividing the implants into multiple segments. This segmentation facilitates the manufacturing and surgical handling of the implants. Approaches are being investigated to securely connect the segments, using materials that biodegrade over time.

Another focus of the project is the development of a simulation model that can be used to virtually test the mechanical load and durability of the implants before they are manufactured. These simulations are intended to help design the implants to withstand the demands of everyday life while supporting the healing process.

The project partners are working closely with medical specialists to ensure that the implants are mature both technically and in terms of clinical use. The overall system will be validated by producing demonstrators that will be tested in real-world scenarios. Furthermore, economic and, in particular, regulatory aspects must be considered.

The project is expected to significantly improve the care of patients with skull defects by developing customized, flexible, and highly biocompatible implants that significantly advance the current state of the art in medical technology. The results of this project are expected to make an important contribution to improving the quality of life of affected patients and sustainably advance surgical practice.