New 3D printing paper published

A recent publication in Trends in Biotechnology highlights the growing use of advanced calcium phosphate-based inks in next-generation bone tissue engineering. The researchers combined INNOTERE's Plotter-Paste-CPC with a bioinspired hydrogel bioink to create multi-material 3D printed scaffolds that unite mechanical stability with biological functionality for bone regeneration applications.

The calcium phosphate phase provided the structural framework of the construct and enabled fabrication of well-defined 3D printed architectures with high print fidelity and useful mechanical strength. Beyond that, the study also demonstrated pronounced biological activity. In vitro, the printed constructs supported cell adhesion, spreading, and proliferation, while osteogenic markers such as RUNX2, BMP2, and OCN were significantly upregulated. In vivo, the multi-material scaffolds promoted osteointegration, angiogenesis, and de novo bone formation.

For INNOTERE, the study is encouraging, because it demonstrates how Plotter-Paste-CPC is increasingly being used in high-level academic research focused on innovative concepts in regenerative medicine for personalized bone repair.