PMMA Bone Cements

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INNOTERE GmbH

Phone: +49 351 2599 9410

Fax: +49 351 2599 9429

Mail: research[at]innotere.de

PMMA-based bone cement is one of the most common biomaterials implanted with direct contact to bone tissue and is increasingly used for minimal invasive stabilization of osteoporotic fractures, especially of the vertebra (vertebroplasty). However, most conventional PMMA bone cements are not optimized for minimal invasive treatment of fractured osteoporotic bone. Limited injectability, complex and unreliable handling properties due to increasing viscosity during setting, a narrow application window and biomechanical mismatch with osteoporotic bone are known disadvantages. Furthermore, PMMA bone cements generally show poor bioactivity or missing osteoconductivity, respectively, which prevents the implanted material from being actively integrated into bone.


Therefore, our activities are focused on new formulations of easily injectable, bioactive polymeric bone cements applicable in many clinically relevant indications with special emphasis on the requirements of minimal invasive application in osteoporotic fractures.

One of INNOTERE's innovative developments is a ready-to-use 2-paste PMMA cement system with significantly improved handling properties. It is based on two paste components separately stored in a double-chamber syringe. By means of a static mixer, both components can be mixed directly at the operation site, which initiates the cement setting reaction. The innovative material system features:

  • a constant cement viscosity during application

  • an unlimited application time, also allowing interruption of the surgical procedure

  • significantly reduced monomer vapor release

  • simplified, low-cost application system

A further innovation by INNOTERE is a bioactive acrylic bone cement, which shows a significantly higher bone affinity index compared to conventional non-modified PMMA bone cements, indicating a highly significant increase of bioactivity. Furthermore, the bioactivation concept does not deteriorate important material properties like mechanics (compressive strength, bending strength), setting reaction (dough and setting time, hardening temperature) and monomer release. The bioactivation technology is of general use and can be applied to commercial available or customized PMMA bone cements.

Featured Publications

  • In vivo evaluation of bioactive PMMA-based bone cement with unchanged mechanical properties in a load-bearing model on rabbits. Fottner A, Nies B, Kitanovic D, Steinbrück A, Hausdorf J, Mayer-Wagner S, Pohl U, Jansson V J Biomater Appl 2015

  • Physicochemical and cell biological characterization of PMMA bone cements modified with additives to increase bioactivity. Wolf-Brandstetter C, Roessler S, Storch S, Hempel U, Gbureck U, Nies B, Bierbaum S, Scharnweber D J Biomed Mater Res B Appl Biomater 2013

  • Mechanical properties and drug release behavior of bioactivated PMMA cements. Vorndran E, Spohn N, Nies B, Rößler S, Storch S, Gbureck U J Biomater Appl 2012

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