Injectable calcium phosphate bone cement

Background

Calcium phosphate bone cements (CPC) are potentially highly valuable materials for filling of bone defects and bone augmentation by minimal invasive application via percutaneous injection. Presently available products however need to be mixed very thoroughly within a narrow window of powder to liquid ratio in order to give an injectable paste or are not injectable at all.

Injectable calciumphosphate bone cement

The objective of our present research is the preparation of calcium phosphate cements as stable and ready-to-use pastes with simplified mixing or no need for mixing at all.

At the same time these new calcium phosphate cements should retain all the desirable properties of conventional CPC counterparts like sufficient mechanical properties, good biocompatibility, and resorbability.

Printing of three-dimensional complex structures and scaffolds

InnoTERE’s calcium phosphate bone cement with a stable pasty consistency can be used for printing scaffolds e.g. for tissue engineering research. In coopereation with the Fraunhofer IWS Dresden and utilizing GeSiM’s Bio-Scaffold Printer suitable three-dimensional structures can be easily obtained. In vitro experiments at the Max Bergmann Center of Biomaterials (research group now at the Center for Translational Bone, Joint and Soft Tissue Research) with human mesenchymal stem cells (hMSC) showed successful cell adhesion onto the material’s surface and cellular ingrowth into the complex structure. Furthermore, the addition of osteogenic media induce cell differentiation of the hMSC into osteoblasts.

The obtained scientific results will be published in a renowned journal soon.

Figures

Application of injectable calcium phosphate bone cement through a catrige mixing system (above) or a syringe (below) into water.
Excellent cohesion of the smooth applicable cement paste and no particle release distinguishes from other paste-like mineral bone cements.